Technology Transfer
Available Technologies
Multiple Path Particle Dosimetry Model (MPPD v 2.0)
A Model for Human and Rat Airway Particle Dosimetry
Inventors and Developers
The multiple-path particle dosimetry (MPPD) model was developed jointly by the CIIT Centers for Health Research (CIIT) and the Dutch National Institute for Public Health and the Environment (RIVM). Members of the CIIT project team are O. T. Price and B. Asgharian. Members of the RIVM project team are F. R. Cassee and R. de Winter-Sorkina.
Applications
The MPPD model is a computational model that can be used for estimating human and rat airway particle dosimetry. The model is applicable to risk assessment, research, and education.
The MPPD model calculates the deposition and clearance of monodisperse and polydisperse aerosols in the respiratory tracts of rats
and human adults and children (deposition only) for particles ranging in size from ultrafine (0.01 µm) to coarse (20 µm). The models are based on
single-path and multiple-path methods for tracking air flow and calculating aerosol deposition in the lung. The single-path method calculates deposition in a typical path per airway
generation, while the multiple-path method calculates particle deposition in all airways of the lung and provides lobar-specific and airway-specific information.
Within each airway, deposition is calculated using theoretically derived efficiencies for deposition by diffusion, sedimentation, and impaction within
the airway or airway bifurcation. Filtration of aerosols by the head is determined using empirical efficiency functions. The MPPD model includes calculations
of particle clearance in the lung following deposition.
Eight tutorials are provided so that the user can learn to interact with the software.
References
Anjilvel, S. and Asgharian, B. (1995). A multiple-path model of particle deposition in the rat lung. Fundam. Appl. Toxicol. 28, 41-50.
National Institute for Public Health and the Environment (RIVM) (2002). Multiple Path Particle Dosimetry Model (MPPD v 1.0): A Model for Human and Rat Airway Particle Dosimetry. Bilthoven, The Netherlands. RIVA Report 650010030.
Patent Status
None. A patent is not being pursued.
License Terms
The MPPD software is now available for download from
the CIIT website.
Copies of the MPPD software are also available on compact disk from
the CIIT Centers for
Health
Research
(CIIT):
Jeanne Galbo
Telephone: 919-558-1389
E-mail: galbo@thehamner.org