Scientists

Mark Sochaski

Mark Sochaski

Education

B.S., chemistry and biochemistry, University of Manitoba, Canada, 1994.
M.S., environmental chemistry, University of South Carolina, 1998.
Ph.D., analytical chemistry, University of South Carolina, 2000.

Research

My research interests involve the development, validation, and application of assays for the analysis of analytes and their metabolites in biological matrices, the quantitative and qualitative analysis of proteins by mass spectrometry, and the identification of biological markers of chemical stress. Current projects include the development of assays for the analysis of genistein, dibutylphthalate, fenitrothion, testosterone, and their metabolites in tissue samples as well as the analysis of posttranslational modification of proteins exposed to chlorine.

Selected Publications

Sochaski, M. A., McManus, B., Struve, M. F., Wallace, D. G., and Dorman, D. C. (2007). Inhibition and recovery of maternal and foetal cholinesterase enzymes following fenitrothion administration in CD rats. Xenobiotica 37, 19-29.

Yu, Y., Thorpe, S. R., Jenkins, A. J., Shaw, J. N., Sochaski, M. A., McGee, D., Aston, C. E., Orchard, T. J., Silvers, N., Peng, Y. G., McKnight, J. A., Baynes, J. W., and Lyons, T. J., and The DCCT/EDIC Research Group. (2006). Advanced glycation end-products and methionine sulphoxide in skin collagen of patients with type 1 diabetes. Diabetologia 49, 2488-2498.

Pasquale-Styles, M. A, Sochaski, M. A., Dorman, D. C., and Krell, W. (2006). Fatal bromethalin poisoning. J. Forensic Sci. 51, 1154-1157.

Soucy, N. V., Parkinson H. D., Sochaski M. A., and Borghoff, S. J. (2005). Kinetics of genistein and its conjugated metabolites in pregnant Sprague-Dawley rats following single and repeated genistein administration. Toxicol. Sci. 90(1), 230-240.

Sochaski, M. A., Bartfay, W. J., Thorpe, S. R., Baynes, J. W., Bartfay, E., Lehotay, D. C., and Liu, P. P. (2002). Lipid peroxidation and protein modification in a mouse model of chronic iron overload. Metabolism 51, 645-651.

Sochaski, M. A., Jenkins, A. J., Lyons, T. J., Thorpe, S. R., and Baynes, J. W. (2001). Isotope dilution gas chromatography/mass spectrometry method for the determination of methionine sulfoxide in protein. Anal. Chem. 73, 4662-4667.

Shaw, T. J., Moore, W. S., Kloepfer, J., and Sochaski, M. (1998). The flux of barium to the coastal waters of the southeastern USA: the importance of submarine groundwater discharge. Geochim. Cosmochim. Acta 62, 3047-3054.