Scientists

Julia S. Kimbell

Julia S. Kimbell

Education

B.A., mathematics, Middlebury College, Middlebury, Vermont, 1982.
M.A., mathematics, Duke University, Durham, North Carolina, 1984.
Ph.D., mathematics, Duke University, Durham, North Carolina, 1988.
Postdoctoral training, CIIT Centers for Health Research, 1989-1992.

Research

My research involves the effects of nasal anatomy and respiratory airflow patterns on the uptake and deposition of inhaled gases and particles in the nasal passages of rodents, primates, and humans. These effects are studied using three-dimensional, computational fluid dynamics models of airflow and of gas and particle transport. Research efforts are currently focused on both toxicologic and therapeutic outcomes of gas uptake and particulate deposition in the nasal passages. We are particularly interested in whether differences in nasal anatomy among human individuals due to age, gender, and race affect nasal uptake and deposition.

Selected Publications

Garcia G. J. M., Bailie N., Martins D. A., and Kimbell J. S. (2007). Atrophic rhinitis: a CFD study of air conditioning in the nasal cavity. J. Appl. Physiol. In press.

Carey, S. A., Minard, K. R., Trease, L. L., Wagner, J. G., Garcia, G. J. M., Ballinger, C. A., Kimbell, J. S., Plopper, C. G., Corley, R. A., Postlethwait, E. M., and Harkema, J. R. (2007). Three-dimensional mapping of ozone-induced injury in the nasal airways of monkeys using magnetic resonance imaging and morphometric techniques. Toxicol. Pathol. 35, 27-40.

Kimbell, J. S., Segal., R. A., Asgharian, B., Wong, B. A., Schroeter, J. D., Southall, J. P., Dickens, C. J., Brace, G., and Miller, F. J. (2007). Characterization of deposition from current nasal spray devices using a computational fluid dynamics model of the human nasal passages. J. Aerosol Med. 20(1), 59-74.

Kimbell, J. S. (2006). Nasal dosimetry of inhaled gases and particles: Where do inhaled agents go in the nose? Toxicol. Pathol. 34, 270-273.

Schroeter, J. D., Kimbell, J. S., Andersen, M. E., and Dorman, D. C. (2006). Use of a pharmacokinetic-driven computational fluid dynamics model to predict nasal extraction of hydrogen sulfide in rats and humans. Toxicol. Sci. 94(2), 359 -367.

Schroeter, J. D., Kimbell, J. S., and Asgharian B. (2006). Analysis of particle deposition in the turbinate and olfactory regions using a human nasal computational fluid dynamics model. J. Aerosol Med. 19(3), 301-313.

Schroeter, J. D., Kimbell, J. S., Bonner, A. M., Roberts, K. C., Andersen, M. E., and Dorman, D. C. (2006). Incorporation of tissue reaction kinetics in a computational fluid dynamics model for nasal extraction of inhaled hydrogen sulfide in rats. Toxicol. Sci. 90(1), 198-207.

Wexler, D., Segal, R. A., and Kimbell, J. S. (2005). Aerodynamic effects of inferior turbinate reduction: Computational fluid dynamics simulation. Arch. Otolaryngol. Head Neck Surg. 131, 1102-1107.

Conolly, R. B., Kimbell, J. S., Janszen, D. B., Schlosser, P. M., Kalisak, D. L., Preston, J., and Miller, F. J. (2004). Human respiratory tract cancer risks of inhaled formaldehyde: Dose-response predictions derived from biologically-motivated computational modeling of a combined rodent and human dataset. Toxicol. Sci. 82, 279-296.

Kelly, J. T., Asgharian, B., Kimbell, J. S., and Wong, B. A. (2004). Particle deposition in human nasal airway replicas manufactured by different methods. Part I: Inertial regime particles. Aerosol Sci. Technol. 38, 1063-1071.

Kelly, J. T., Asgharian, B., Kimbell, J. S., and Wong, B. A. (2004). Particle deposition in human nasal airway replicas manufactured by different methods. Part II: Ultrafine particles. Aerosol Sci. Technol. 38, 1072-1079.

Georgieva, A. V., Kimbell, J. S., and Schlosser, P. M. (2003). A distributed-parameter model for formaldehyde uptake and disposition in the rat nasal lining. Inhal. Toxicol. 15:1435-1463.

Conolly, R. B., Kimbell, J. S., Janszen, D. B., Schlosser, P. M., Kalisak, D. L., Preston, J., and Miller, F. J. (2003). Biologically motivated computational modeling of formaldehyde carcinogenicity in the F344 rat. Toxicol. Sci. 75, 432-437.

Schlosser, P. M., Lilly, P. D., Conolly, R. B., Janszen, D. B., and Kimbell, J. S. (2003). Benchmark dose risk assessment for formaldehyde using airflow modeling and a single-compartment DNA-protein cross-link dosimetry model to estimate human equivalent doses. Risk Anal. 23, 473-487.

Conolly, R. B., Kimbell, J. S., Janszen, D. B., and Miller, F. J. (2002). Dose-response for formaldehyde-induced cytotoxicity in the human respiratory tract. Regul. Toxicol. Pharmacol. 35, 32-43.

Moulin, F. J., Brenneman, K. A., Kimbell, J. S., and Dorman, D. C. (2002). Predicted regional flux of hydrogen sulfide correlates with distribution of nasal olfactory lesions in rats. Toxicol. Sci. 66, 7-15.

Kelly, J. T., Kimbell, J. S., and Asgharian, B. (2001). Deposition of fine and coarse aerosols in a rat nasal mold. Inhal. Toxicol. 13, 577-588.

Kimbell, J. S., Overton, J. H., Subramaniam, R. P., Schlosser, P. M., Morgan, K. T., Conolly, R. B., and Miller, F. J. (2001). Dosimetry modeling of inhaled formaldehyde: Binning nasal flux predictions for quantitative risk assessment. Toxicol. Sci. 64, 111-121.

Kimbell, J. S., Subramaniam, R. P., Gross, E. A., Schlosser, P. M., and Morgan, K. T. (2001). Dosimetry modeling of inhaled formaldehyde: comparisons of local flux predictions in the rat, monkey, and human nasal passages. Toxicol. Sci. 64, 100-110.

Overton, J. H., Kimbell, J. S., and Miller, F. J. (2001). Dosimetry modeling of inhaled formaldehyde: the human respiratory tract. Toxicol. Sci. 64, 122-134.

Conolly, R. B., Lilly, P. D., and Kimbell, J. S. (2000). Simulation modeling of the tissue disposition of formaldehyde to predict nasal DNA-protein cross-links in F344 rats, rhesus monkeys, and humans. Environ. Health Perspect. 108 (Supplement 5), 919-924.

Frederick, C. B., Bush, M. L., Lomax, L. G., Black, K. A., Finch, L., Kimbell, J. S., Morgan, K. T., Subramaniam, R. P., Morris, J. B., and Ultman, J. S. (1998). Application of a hybrid computational fluid dynamics and physiologically-based inhalation model for interspecies dosimetry extrapolation of acidic vapors in the upper airways. Toxicol. Appl. Pharmacol. 152, 211-231.

Kepler, G. M., Richardson, R. B., Morgan, K. T., and Kimbell, J. S. (1998). Computer simulation of inspiratory nasal airflow and inhaled gas uptake in a rhesus monkey. Toxicol. Appl. Pharmacol. 150, 1-11.

Subramaniam, R. P., Richardson, R. B., Morgan, K. T., Guilmette, R. A., and Kimbell, J. S. (1998). Computational fluid dynamics simulations of inspiratory airflow in the human nose and nasopharynx. Inhal. Toxicol. 10, 91-120.

Kimbell, J. S., Godo, M. N., Gross, E. A., Joyner, D. R., Richardson, R. B., and Morgan, K. T. (1997). Computer simulation of inspiratory airflow in all regions of the F344 rat nasal passages. Toxicol. Appl. Pharmacol. 145, 388-398.

Kimbell, J. S., Gross, E. A., Richardson, R. B., Conolly, R. B., and Morgan. K. T. (1997). Correlation of regional formaldehyde flux predictions with the distribution of formaldehyde-induced squamous metaplasia in F344 rat nasal passages. Mutat. Res. 380, 143-154.

Cohen Hubal, E.A., Kimbell, J.S., and Fedkiw, P.S. (1996). Incorporation of nasal-lining mass-transfer resistance into a CFD model for prediction of ozone dosimetry in the upper respiratory tract. Inhal. Toxicol. 8:831-857.

Kimbell, J. S., Gross, E. A., Joyner, D. R., Godo, M. N., and Morgan, K. T. (1993). Application of computational fluid dynamics to regional dosimetry of inhaled chemicals in the upper respiratory tract of the rat. Toxicol. Appl. Pharmacol. 121, 253-263.